Dmitry Volodkin
Nottingham Trent University, UK
Title: Planar and curved self-assembled polymer multilayers - novel approaches for biomolecule immobilization and release on demand
Biography
Biography: Dmitry Volodkin
Abstract
Polymer-based and composite multilayers have been widely used over the past decade towards biological and non-biological applications. Our research is focused on assembly of 2D and 3D multilayer structures (planar films and capsules) aiming at biological applications. Such tailor-made structures have fine-tuned architecture, controlled thickness from nano to micro, adjusted softness from Pa to GPa, and almost unlimited variety of functional compounds. In this talk I present our recent findings in the mechanism of multilayer assembly, physical-chemical approaches to immobilize biomolecules (proteins, nucleic acids, small drugs, etc) and to release/deliver the biomolecules in controlled manner. The externally triggered release on demand by IR-laser light and cellular studies including extra- and intra-cellular delivery is considered. The developed structures offering localized, remote, and non-invasive release of biomolecules are indispensable for applications in diagnostics, toxicology, tissue engineering, and especially for single cell studies where high precision of biomolecule delivery in space and time is highly desirable