Tzong-Yuan Juang
China Medical University, Taiwan
Title: Development of fluorescent water-soluble hyperbranched polymers in nanomaterials and biomaterials
Biography
Biography: Tzong-Yuan Juang
Abstract
In this study, we intend to used self-condensation of an AB2 monomer to prepare fluorescent hyperbranched poly (amido acids) (HBPAAs) featuring wholly aliphatic backbones, multiple terminal CO2H units, and many internal tertiary amino and amido moieties. Because tertiary amino groups are known to behave as fluorescent centers in dendritic structures, in this study we wish to prepared AB2 monomer through an efficient synthetic scheme, involving blocking and deblocking processes, in high yield. Visible blue photoluminescence self-emissions would be generated from the non-conjugated HBPAAs in aqueous solution; that is, bright blue fluorescence behavior, with emission peaks at 395 nm and fluorescence QYs of up to 23%, appeared when the branching tertiary amino moieties were embedded in a self-polymerized globular confinement. These amphiphilic HBPAAs also have potential for use as tracing nanocarriers and molecular-level containers. Self-condensation of this AB2 building block to construct water-soluble globular architectures with desired fluorescence properties appears to be a facile approach toward dendritic macromolecules with labeling-delivery applications.