Biomaterials

Biography

Biography: Tzong-Yuan Juang

Abstract

In this study, we intend to used self-condensation of an AB₂ monomer to prepare fluorescent hyperbranched poly (amido acids) (HBPAAs) featuring wholly aliphatic backbones, multiple terminal CO₂H units, and many internal tertiary amino and amido moieties. Because tertiary amino groups are known to behave as fluorescent centers in dendritic structures, in this study we wish to prepared AB₂ monomer through an efficient synthetic scheme, involving blocking and deblocking processes, in high yield. Visible blue photoluminescence self-emissions would be generated from the non-conjugated HBPAAs in aqueous solution; that is, bright blue fluorescence behavior, with emission peaks at 395 nm and fluorescence QYs of up to 23%, appeared when the branching tertiary amino moieties were embedded in a self-polymerized globular confinement. These amphiphilic HBPAAs also have potential for use as tracing nanocarriers and molecular-level containers. Self-condensation of this AB₂ building block to construct water-soluble globular architectures with desired fluorescence properties appears to be a facile approach toward dendritic macromolecules with labeling-delivery applications.