Aurica P Chiriac
“Petru Poni†Institute of Macromolecular Chemistry, Romania
Title: Preparation of a new drug delivery carrier based on hydrogels of hyaluronic acid crosslinked with poly(itaconic anhydride-co-3, 9-divinyl-2, 4, 8, 10-tetraoxaspiro (5.5) undecane) copolymers
Biography
Biography: Aurica P Chiriac
Abstract
The study reports the preparation of the new drug carrier gel system based on poly(itaconic anhydride-co-3, 9-divinyl-2, 4, 8, 10-tetraoxaspiro (5.5) undecane) (PITAU) copolymer and hyaluronic acid (HA-PITAU). In relation with its composition PITAU has specific conformational structure owing to the unsaturated double bond of 3, 9-divinyl-2, 4, 8, 10-tetraoxaspiro (5.5) undecane comonomer and the spiroacetal moiety, giving macromolecular chains with network type structures. SEM microscopy and chemical imagining evidence the homogeneous porous structure of the new 3D network. NIR-chemical imaging technique prove the successful preparation of polymeric drug delivery system by using indomethacin (IND) as bioactive model substance. The dissolution data revealed the interdependence of the ratio between the two compounds and attaining optimum loading capacity. In vivo study demonstrated that HA_ PITAU and HA_ PITAU_IND determined similar blood parameters modifications and biochemical responses with distilled water, after intraperitoneal administration in mice. Systemic administration of the tested substances in mice did not modify their immune reactivity comparing with control group. All these results reveal a good in vivo biocompatibility. The bioactive compound caused a significant antinociceptive effect occurring after 60 minutes and lasts about 3 hours in tail flick test.