Biomaterials

Biography

Biography: Omoruyi. G. Idemudia

Abstract

The development of new molecules (materials) with novel properties, having broad spectrum therapeutic activities that will become alternative medicinal drugs have attracted a lot of research attention due to the emergence of medicinal drug’s limitations such as disease resistance to them and their toxicity effects among others. Also compounds containing metal centres (e.g cis-platin) have been employed for many years as therapeutic agents because of their biological activities, and as such synthesized organic/inorganic compounds are coordinated with metal ions in an effort to increase their potency. Acylpyrazolones have been employed as pharmaceuticals as well as analytical reagent and their application as coordination complexes with transition metal ions have being well established. Through a condensation reaction with amines they form a more chelating and superior group of compounds known as azomethines. 4-benzoyl-3-methyl-1-phenyl-2-pyrazolin-5-one was reacted with sulphanilamide to get a new sulphanilamide azomethine which was further reacted with palladium and platinum, in an effort towards the discovery of transition metal based synthetic drugs. The compounds were characterized/identified by means of analytical, spectroscopic, thermogravimetric analysis TGA, as well as x-ray crystallography. The bidentate ON ligand forms a square planar geometry on coordinating with metal ions. Using the disc diffusion technique to screen the synthesized compounds at 20 mg/ml against selected bacterial isolates in triplicates, potential bactericides were identified. Their bioactivity vary, with the metal complexes showing higher antibacterial activity at an MIC value of 0.63 mg/ml. Similarly, ligand and complexes also showed antioxidant scavenging properties against 2, 2-diphenyl-1-picrylhydrazyl DPPH radical at 0.5mg/ml relative to Ascorbic acid (standard drug).